Evidence-based supplement guides. No hype, no paid placements — just what the science actually says.
The six supplements with the strongest evidence for living longer — from D3+K2 to NAD+ and Urolithin A.
10 min read · April 2026 VitaminsThe calcium paradox explained — and why taking D3 alone for years may be increasing your cardiovascular risk.
7 min read · April 2026 Sleep & RecoveryNot all magnesium is equal. Here's which form works for sleep — and which one to skip entirely.
6 min read · April 2026 LongevityA Harvard professor has taken 1 gram of this daily for years. Here's the mechanism — and what high-dose resveratrol actually does to how you feel.
9 min read · April 2026 LongevityHonest comparison of the two main NAD+ supplements, with absorption data, cost analysis, and why TMG is non-negotiable.
8 min read · April 2026 Blood SugarA 2008 RCT put berberine head-to-head with metformin. The results were closer than most people realize.
8 min read · April 2026 Heart HealthThe form of CoQ10 you take determines how much actually reaches your mitochondria. Most people over 40 are using the wrong one.
7 min read · April 2026 Heart HealthThree supplements with real cardiovascular clinical data: CoQ10, nattokinase, and omega-3 cod liver oil.
9 min read · April 2026 Omega-3Same EPA and DHA, very different nutritional profiles. Plus: why rancid fish oil is worse than none at all.
7 min read · April 2026 LongevityA tiered approach starting where the evidence is strongest, with real monthly costs at each level.
9 min read · April 2026 LongevityZombie cells drive chronic inflammation. Quercetin has human clinical data for clearing them through pulse dosing.
8 min read · April 2026 Heart HealthAn enzyme from fermented soybeans with measurable blood pressure reduction and fibrinolytic activity in clinical trials.
7 min read · April 2026 Men's HealthCoQ10, NAD+, D3+K2, and zinc picolinate targeted at the specific metabolic and hormonal changes after 40.
9 min read · April 2026 Women's HealthD3+K2, magnesium, NAD+, and liposomal glutathione for the specific challenges of women in midlife.
9 min read · April 2026 Gut HealthCentenarians consistently have more of it. A Nature Medicine trial confirmed its metabolic benefits. Here's what to know.
8 min read · April 2026 DetoxUsed in hospital ERs for liver protection, NAC is also a powerful glutathione precursor for daily antioxidant support.
8 min read · April 2026 AntioxidantsStandard oral glutathione is mostly destroyed by digestion. Liposomal delivery changes the bioavailability equation significantly.
7 min read · April 2026 LongevityThis polyamine triggers autophagy. A PRISM trial found cognitive improvements in older adults. Here's the honest assessment.
7 min read · April 2026 MineralsAt $12.95 per month, boron increases free testosterone by reducing SHBG and improves vitamin D activation efficiency.
7 min read · April 2026 Anti-AgingAnti-glycation, muscle pH buffering, and neuroprotection. Especially valuable for vegans who miss dietary carnosine.
7 min read · April 2026 LongevityResveratrol has the celebrity endorsements. Pterostilbene has 80% bioavailability and a longer half-life. Here's the honest comparison.
8 min read · April 2026 Brain HealthThe most researched herbal nootropic has a nuanced evidence base. Here's who benefits and who won't feel much.
7 min read · April 2026 VitaminsMost vitamin E supplements use only tocopherols. The tocotrienol family has stronger evidence for cardiovascular and brain protection.
7 min read · April 2026 PerformanceThe fat burning story is partially true. The cardiac story is more compelling and less talked about.
7 min read · April 2026 LongevityNAD+ synthesis depletes methyl groups. TMG replenishes them and also reduces homocysteine. It's the missing half of every NAD+ protocol.
7 min read · April 2026 Immune HealthZinc oxide (the cheap form in most multivitamins) absorbs poorly. Picolinate absorbs significantly better and the immune effects reflect the difference.
7 min read · April 2026 Immune HealthOver 30 human clinical trials, used in Japanese hospitals for 25 years, and two trials showing HPV clearance.
8 min read · April 2026 SleepMagnesium, glycine, GABA, and L-glutamine: the sleep supplements with real mechanisms, not just relaxation marketing claims.
8 min read · April 2026 Brain HealthAn FDA-qualified health claim, multiple RCTs on memory, and documented cortisol reduction in athletes. This one earns its place.
7 min read · April 2026 LongevityEpigenetic clocks can measure how fast you're aging. Here's how to get tested and what the evidence says you can do about it.
9 min read · April 2026